Application of piezoelectric nanomaterials in cancer therapy
Background: Cancer is a serious threat to human health, the current commonly used treatment methods such as chemotherapy, radiotherapy and surgery have certain limitations and side effects. Therefore, the development of novel, non-invasive, efficient and safe cancer treatment strategies is urgently needed. Piezoelectric nanomaterials are a class of nano-scale materials with piezoelectric effects, which can generate polarized charges under mechanical pressure or ultrasonic waves, thus triggering catalytic reactions to produce REDOX substances such as reactive oxygen species or free radicals. These substances can effectively kill cancer cells while avoiding damage to normal cells. Therefore, piezoelectric nanomaterials have broad application prospects in cancer therapy.
Project Description: This project aims to design and synthesize a new type of piezoelectric nanomaterial, using its piezoelectric catalytic effect under ultrasonic excitation to achieve accurate recognition and response to the tumor microenvironment, so as to achieve efficient, specific and non-invasive cancer treatment effect. This project will adopt a multidisciplinary approach, combining knowledge and technology in materials science, chemistry, biomedicine and other fields, to explore the mechanism of action, optimization conditions and influencing factors of piezoelectric nanomaterials in cancer therapy, and evaluate their anti-cancer effects and biosafety in vitro and animal models.
Project content:
Design and synthesis of piezoelectric nanomaterials: Barium titanate (BaTiO3), which has good piezoelectric properties, biocompatibility and stability, is selected as the basic material. BaTiO3 nanomaterials with different morphologies and compositions are prepared by doping, surface modification, morphology regulation and other methods, and their structure, morphology, piezoelectric properties and catalytic activity are characterized.
The response mechanism of piezoelectric nanomaterials to tumor microenvironment: BaTiO3 nanoplates with Ph-sensitive, oxygen-sensitive or enzyme-sensitive functional groups were designed and constructed using the characteristics of low pH, high reducibility and overexpressed enzymes present in the tumor microenvironment to enable them to undergo structural changes or functional switches at the tumor site, thereby enhancing their response to ultrasound and catalytic efficiency, and reducing the impact on normal tissues.
Anti-cancer effects of piezoelectric nanomaterials in vitro and in animal models: Different types of cancer cells were selected as in vitro experiment objects to evaluate the killing effect of reactive oxygen species or free radicals generated by BaTiO3 nanosheets under different conditions under ultrasonic excitation on cancer cells, and explore its mechanism of action. At the same time, a mouse tumor model was established to observe the distribution, metabolism and excretion of BaTiO3 nanosheet in vivo, as well as the tumor inhibition effect and the influence on normal tissues under ultrasonic stimulation.
Biosafety evaluation of piezoelectric nanomaterials: The biosafety of BaTiO3 nanomaterials in vitro and in vivo was evaluated by detecting the toxicity of batiO3 nanomaterials to normal cells, the hemolysis of blood, the coagulation of serum, and the stimulation of the immune system, and compared with other commonly used nanomaterials.
Topic innovation:
For the first time, the piezoelectric catalytic effect has been applied to the field of cancer treatment, which opens up a new direction for the development of piezoelectric medicine.
Based on the characteristics of the tumor microenvironment, BaTiO3 nanosheets with responsive functional groups were designed and constructed, which realized accurate identification and response to tumor sites, and improved the efficiency and specificity of piezoelectric catalytic therapy.
Considering the structure, morphology, composition and function of piezoelectric nanomaterials, the catalytic performance and stability of piezoelectric nanomaterials under ultrasonic excitation were optimized, which provided a new idea and method for the design of piezoelectric nanomaterials.
The anti-cancer effects and biosafety of piezoelectric nanomaterials in vitro and animal models were evaluated systematically, which provided reliable data support for their clinical application.
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