Project background:


Controlled drug release refers to the encapsulation of drugs in carrier materials, so that the drug is released in the body according to the preset rate, time and location, so as to improve the efficacy and safety of drugs, and reduce the toxic side effects and drug resistance. Polymer materials are a class of materials with excellent biocompatibility, biodegradability, function adjustability and structural diversity, and they have a wide range of application prospects in the field of drug controlled release. Nanotechnology is a discipline that uses the special properties of the nanoscale to create new functions and phenomena, and it plays an important role in the field of biomedicine. Polymer nanocomposites are a class of materials with nanostructures and functions obtained by combining or modifying polymer materials and nanomaterials (such as nanoparticles, nanotubes, nanosheets, etc.), which can achieve new or enhanced properties while having the advantages of both polymer materials and nanomaterials.


Project introduction: This project aims to design and prepare new polymer nanocomposite materials as drug carriers to achieve controlled release of drugs, study their drug release behavior and biocompatibility in vivo and in vitro, and provide a new drug delivery system for the biomedical field. In this paper, several important drug control and release systems are targeted, such as anticancer drugs, antibacterial drugs, anti-inflammatory drugs, etc., and the application mechanism and optimization strategy of polymer nanocomposites in these systems are explored. In this paper, a variety of experimental methods and theoretical calculation methods will be used to characterize and evaluate the structure, properties and properties of polymer nanocomposites, as well as their interactions with drug molecules and biological systems.
Project content:
1. By selecting different types of polymer materials (such as polylactic acid, polyethylene glycol, polycaprolactone, etc.) and nanomaterials (such as gold nanoparticles, carbon nanotubes, graphene oxide, etc.), using different methods (such as self-assembly, blending, covalent bonding, etc.), Polymer nanocomposites with different morphologies (such as spherical, bar, sheet, etc.) and sizes (such as 10~200 nm) were prepared, and their structures were characterized and analyzed.
2. Post-treatment or post-synthetic modification of polymer nanocomposites by introducing different types of functional groups or modifiers (such as targeting ligands, stimulation-response groups, solubilizers, etc.) to change their surface chemical properties and hydrophilicity, and carry out functional characterization and analysis.
3. By selecting different types of drug molecules (such as paclitaxel, doxorubicin, ibuprofen, etc.) and using different methods (such as adsorption, embedding, covalent bonding, etc.), the drug is loaded into the polymer nanocomposite material, and its drug loading and encapsulation rate are determined, and its stability is tested.
4. By measuring the release kinetics curve, release mechanism, release selectivity and other parameters of the polymer nanocomposite for drug molecules, the performance of the polymer nanocomposite in drug release control was evaluated and compared with other drug carriers.
5. By using cell culture and animal model methods, the performance of polymer nanocomposites in vitro and in vivo biocompatibility, biological distribution, drug targeting, drug therapeutic effect and other aspects was studied, and the possible problems and improvement directions were explored.
Topic innovation:
1. This topic will adopt a variety of methods and strategies to prepare polymer nanocomposites with different structures and functions, which will enrich the structural diversity and functional designability of polymer nanocomposites.
2. Aiming at several important drug control and release systems, this topic will optimize the drug loading capacity, encapsulation rate, stability, release performance and targeting of polymer nanocomposites, providing possibilities for realizing efficient drug delivery of polymer nanocomposites.
3. This topic will combine experimental methods and theoretical calculation methods to deeply explore the interaction mechanism and influencing factors between polymer nanocomposites and drug molecules and biological systems, providing theoretical guidance and basis for the structural design and functional optimization of polymer nanocomposites.